About me

Xavier Grau-Bové HR_sq_centratI am a Post Doctoral Research Associate at the Vector Biology department of the Liverpool School of Tropical Medicine, with David Weetman and Martin Donnelly.

I am currently working on the evolution of insecticide resistance adaptations in Anopheles mosquitoes responsible for malaria transmission. The recurrent evolution of new resistance mechanisms in insect vectors is a major obstacle in our current efforts to curb and eradicate infectious diseases like malaria. In particular, I am involved in the analysis of data from the Sanger Institute Anopheles gambiae 1000 genomes project, as well as studying the role of alternative splicing and transcriptome variation in insecticide resistance. Alternative splicing of transcripts is a fast-evolving layer of transcriptomic regulation that bears enormous potential to understand the rapid emergence of resistance mechanisms in natural mosquito populations.

In the past, I have worked with Iñaki Ruiz-Trillo studying the origin of animal multicellularity using comparative genomic analyses of animals and their unicellular relatives. You can learn more about this in my favourite publications from my thesis:

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