I am currently working on the evolution of insecticide resistance adaptations in Anopheles mosquitoes responsible for malaria transmission. The recurrent evolution of new resistance mechanisms in insect vectors is a major obstacle in our current efforts to curb and erradicate infectious diseases like malaria. In particular, I am involved in the analysis of data from the Sanger Institute Anopheles gambiae 1000 genomes project, as well as studying the role of alternative splicing and transcriptome variation in insecticide resistance. Alternative splicing of transcripts is a fast-evolving layer of transcriptomic regulation that bears enormous potential to understand the rapid emergence of resistance mechanisms in natural mosquito populations.
In the past, I have worked with Iñaki Ruiz-Trillo studying the origin of animal multicellularity using comparative genomic analyses of animals and their unicellular relatives. You can learn more about this in my favourite publications from my thesis:
- Dynamics of genomic innovation in the unicellular ancestry of animals (Grau-Bové et al. eLife 2017)
- Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture (Grau-Bové et al. Genome Biology 2018), which I talked about in this post.
- … or in my publication list.